:root {
  /* GeneRoute deep teal (from the logo) – deliberately not the NHS identity palette */
  --bg: #f3f7f7;
  --fg: #1f2d33;
  --muted: #4a5f66;
  --card: #ffffff;
  --border: #d5e0e2;
  --accent: #0b7285;
  --accent-dark: #08505d;
  --accent-soft: #e3f3f4;
  --head-bg: #0e5866;
  --head-fg: #ffffff;
  --head-edge: #3fc1c9;
  --head-focus: #9be7ec;
  --button: #0b7285;
  --button-hover: #08505d;
  --focus: #0b7285;
  --focus-text: #1f2d33;
  --pill-bg: #fff9c4;
  --pill-fg: #4f3d00;
  --changed-bg: #fff4e0;
  --changed-fg: #6b3d00;
  --mark: #fff3a0;
  --thr-bg: #eef2f4;
  --mark-fg: #1f2d33;
  --shadow: 0 1px 2px rgb(33 43 50 / .08);
}
@media (prefers-color-scheme: dark) {
  :root:not([data-theme="light"]) {
    --bg: #0f1b1e; --fg: #e6eeef; --muted: #a5b8bd; --card: #172629; --border: #2c4046;
    --accent: #5ccbd4; --accent-dark: #9fe3e8; --accent-soft: #143a40; --head-bg: #0a3c46; --pill-bg: #4a3d00; --pill-fg: #fff3b0;
    --button: #0f7f8f; --button-hover: #0b6675; --focus: #5ccbd4; --focus-text: #e6eeef; --changed-bg: #45300c; --changed-fg: #ffd9a0; --mark: #6b5a00; --mark-fg: #fff8d0; --thr-bg: #26333c;
    --shadow: none;
  }
}
:root[data-theme="dark"] {
  --bg: #0f1b1e; --fg: #e6eeef; --muted: #a5b8bd; --card: #172629; --border: #2c4046;
  --accent: #5ccbd4; --accent-dark: #9fe3e8; --accent-soft: #143a40; --head-bg: #0a3c46; --pill-bg: #4a3d00; --pill-fg: #fff3b0;
  --button: #0f7f8f; --button-hover: #0b6675; --focus: #5ccbd4; --focus-text: #e6eeef; --changed-bg: #45300c; --changed-fg: #ffd9a0; --mark: #6b5a00; --mark-fg: #fff8d0; --thr-bg: #26333c;
  --shadow: none;
}
* { box-sizing: border-box; }
html { scroll-padding-top: 56px; }
body { margin: 0; background: var(--bg); color: var(--fg); font: 16px/1.5 system-ui, -apple-system, "Segoe UI", Roboto, "Helvetica Neue", sans-serif; }
.wrap { max-width: 1180px; margin: 0 auto; padding-inline: 16px; }
a { color: var(--accent); }
a:hover { color: var(--accent-dark); }
:focus-visible { outline: 3px solid var(--focus); outline-offset: 2px; }
.site-head :focus-visible { outline-color: var(--head-focus); }
[tabindex="-1"]:focus, [tabindex="-1"]:focus-visible { outline: none; box-shadow: none; }
.muted { color: var(--muted); }
.small { font-size: .9rem; }
.code { font-weight: 700; font-variant-numeric: tabular-nums; }
.visually-hidden, #search label { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; }
kbd { font: .85em/1 ui-monospace, SFMono-Regular, Menlo, monospace; padding: 2px 5px; border: 1px solid var(--border); border-bottom-width: 2px; border-radius: 3px; background: var(--card); }
mark { background: var(--mark); color: var(--mark-fg); padding: 0 1px; border-radius: 2px; }
mark.current { outline: 2px solid var(--accent); }
button.link { font: inherit; font-size: .9rem; background: none; border: 0; padding: 0; color: var(--accent); text-decoration: underline; cursor: pointer; }

/* Header */
.site-head { background: var(--head-bg); color: var(--head-fg); padding: 14px 0; border-bottom: 4px solid var(--head-edge); }
.site-head a { color: var(--head-fg); }
.head-row { display: flex; align-items: center; justify-content: space-between; gap: 12px 16px; }
.brand { display: flex; align-items: center; gap: 12px; min-width: 0; }
.brand-mark { flex: none; border-radius: 50%; background: #fff; box-shadow: 0 1px 3px rgb(0 0 0 / .25); }
.site-head a.brand-home { display: inline-block; color: var(--head-fg); font-size: .75rem; font-weight: 600; letter-spacing: .06em; text-transform: uppercase; text-decoration: none; opacity: .9; }
.site-head a.brand-home:hover { text-decoration: underline; opacity: 1; }
.brand-home::after { content: " ›"; }
.brand h1 { margin: 0; font-size: 1.4rem; line-height: 1.2; }
.brand h1 a { text-decoration: none; }
.brand p { margin: 2px 0 0; font-size: .9rem; opacity: .9; }
.pill { display: inline-block; vertical-align: middle; margin-left: 6px; padding: 2px 8px; border-radius: 999px;
  background: var(--pill-bg); color: var(--pill-fg); font-size: .75rem; font-weight: 600; }
.head-link { font-size: .9rem; white-space: nowrap; }
main { padding: 24px 0 48px; }

/* Search and filters */
.intro { color: var(--muted); max-width: 72ch; margin: 0 0 14px; }
#search { display: flex; gap: 8px; max-width: 760px; }
#q { flex: 1; min-width: 0; padding: 10px 12px; font: inherit; font-size: 1.05rem; color: var(--fg); background: var(--card); border: 2px solid var(--fg); border-radius: 4px; }
#search button { font: inherit; font-weight: 600; color: #fff; background: var(--button); border: 0; border-radius: 6px; padding: 0 18px; cursor: pointer; margin-bottom: 4px; }
#search button:hover { background: var(--button-hover); }
#search button:active { transform: translateY(1px); }
.hint { margin: 6px 0 14px; }
#filter-panel { background: var(--card); border: 1px solid var(--border); border-radius: 4px; padding: 10px 14px; box-shadow: var(--shadow); max-width: 100%; }
#filter-panel > summary { cursor: pointer; font-weight: 600; }
#filters { display: flex; flex-wrap: wrap; gap: 12px 16px; align-items: flex-end; margin: 10px 0 2px; }
#filter-fields { display: grid; grid-template-columns: repeat(4, minmax(0, 1fr)); gap: 12px 16px; flex: 1 1 640px; min-width: 0; }
#filters label { display: grid; gap: 2px; font-size: .85rem; font-weight: 600; color: var(--muted); min-width: 0; }
#filters select { width: 100%; min-width: 0; font: inherit; font-weight: 400; color: var(--fg); background: var(--card); border: 1px solid var(--muted); border-radius: 4px; padding: 6px 8px; }
#filters .check { display: flex; grid-auto-flow: column; align-items: center; gap: 6px; padding-bottom: 6px; color: var(--fg); font-weight: 400; font-size: .95rem; }
.result-bar { display: flex; align-items: center; gap: 8px 12px; flex-wrap: wrap; margin: 16px 0 10px; }
#count { margin: 0; font-weight: 600; }
#active { display: flex; flex-wrap: wrap; gap: 6px; }
.chip { display: inline-block; padding: 1px 8px; border-radius: 999px; background: var(--accent-soft); color: var(--fg); font-size: .8rem; font-weight: 500; }
.chip.changed { background: var(--changed-bg); color: var(--changed-fg); }
button.chip.removable { font: inherit; font-size: .85rem; border: 1px solid var(--accent); cursor: pointer; padding: 2px 10px; }
button.chip.removable span { font-weight: 700; margin-left: 2px; }
#gene-hint { margin: 0 0 12px; padding: 8px 12px; background: var(--accent-soft); border-left: 4px solid var(--accent); border-radius: 4px; }

/* Results */
.group { margin: 0 0 18px; }
.group-head { position: sticky; top: 0; z-index: 2; margin: 0 0 8px; padding: 8px 2px; font-size: 1.05rem; background: var(--bg); border-bottom: 2px solid var(--border); }
.group-head .muted { font-weight: 400; font-size: .9rem; }
.results { list-style: none; margin: 0; padding: 0; display: grid; gap: 8px; }
.results .row { display: grid; gap: 3px; padding: 11px 14px; background: var(--card); border: 1px solid var(--border); border-left: 4px solid var(--accent);
  border-radius: 4px; color: var(--fg); text-decoration: none; box-shadow: var(--shadow); }
a.row:hover { border-color: var(--accent); }
a.row:hover .row-name { text-decoration: underline; }
.row-head .code { color: var(--accent); }
.row-name { font-weight: 600; }
.row-meta { color: var(--muted); font-size: .9rem; display: flex; flex-wrap: wrap; gap: 4px 6px; align-items: center; }
.row-why { font-size: .85rem; color: var(--muted); font-style: italic; }
.row-snip { font-size: .88rem; color: var(--muted); }
.results li.row .row-head { text-decoration: none; color: var(--fg); }
.results li.row .row-head:hover .row-name { text-decoration: underline; }
.more { margin: 12px 0 0; text-align: center; }
.more button { font: inherit; color: var(--accent); background: var(--card); border: 1px solid var(--accent); border-radius: 4px; padding: 6px 16px; cursor: pointer; }
.more button:hover { background: var(--accent-soft); }
.empty { padding: 16px; background: var(--card); border: 1px solid var(--border); border-radius: 4px; }

/* Indication page */
.back { margin: 0 0 8px; }
#detail h2 { font-size: clamp(1.4rem, 3.5vw, 1.9rem); line-height: 1.25; margin: 0 0 8px; }
#detail h2 .code { color: var(--accent); }
.meta { display: flex; flex-wrap: wrap; gap: 6px; margin: 0 0 10px; }
.toolbar { display: flex; flex-wrap: wrap; align-items: center; gap: 8px; margin: 0 0 12px; }
.toolbar button { font: inherit; font-size: .88rem; color: var(--accent); background: var(--card); border: 1px solid var(--accent); border-radius: 4px; padding: 3px 10px; cursor: pointer; }
.toolbar button:hover { background: var(--accent-soft); }
.search-note { margin: 0 0 12px; padding: 8px 12px; background: var(--mark); color: var(--mark-fg); border-radius: 4px; }
.search-note .link { color: inherit; }
.sources { background: var(--accent-soft); border: 1px solid var(--border); border-radius: 4px; padding: 10px 14px; margin: 0 0 16px; }
.sources h3 { margin: 0 0 6px; font-size: .95rem; }
.sources p { margin: 0; }
.src-links { display: flex; flex-wrap: wrap; gap: 6px 8px; margin: 0 0 6px !important; }
a.src { display: inline-block; padding: 3px 10px; background: var(--card); border: 1px solid var(--accent); border-radius: 999px; font-size: .9rem; text-decoration: none; }
a.src:hover { text-decoration: underline; }
a.ext::after { content: "↗"; display: inline-block; margin-left: 3px; font-size: .85em; text-decoration: none; }
.cols { display: grid; grid-template-columns: minmax(0, 1.15fr) minmax(0, 1fr); gap: 16px; align-items: start; }
.cols > div { display: grid; gap: 16px; }
.block { background: var(--card); border: 1px solid var(--border); border-radius: 4px; padding: 16px 18px; box-shadow: var(--shadow); }
.block h3 { margin: 0 0 10px; font-size: 1.15rem; }
.block ul { margin: 0 0 8px; padding-left: 20px; }
.block p { margin: 0 0 8px; }
.source { margin-top: 12px !important; color: var(--muted); }
.crit-list { list-style: none; padding: 0 !important; margin: 0; display: grid; gap: 6px; }
.crit-list .lv1 { margin-left: 22px; } .crit-list .lv2 { margin-left: 44px; } .crit-list .lv3 { margin-left: 66px; }
.crit-list .crit-sub { font-weight: 700; margin-top: 8px; }
.crit-list .crit-join { font-size: .8rem; font-weight: 700; letter-spacing: .06em; color: var(--muted); display: flex; align-items: center; gap: 8px; }
.crit-list .crit-join::before, .crit-list .crit-join::after { content: ""; height: 1px; background: var(--border); flex: 0 0 18px; }
.crit-list .crit-join::after { flex: 1; }
.crit-list .mk { font-weight: 700; }
.crit-head { display: flex; flex-wrap: wrap; align-items: baseline; justify-content: space-between; gap: 4px 12px; }
.layout-switch { font: inherit; font-size: .85rem; color: var(--accent); background: var(--card); border: 1px solid var(--accent); border-radius: 4px; padding: 2px 10px; cursor: pointer; }
.layout-switch:hover { background: var(--accent-soft); }
.crit-help { margin: -4px 0 12px !important; }
/* Formatted criteria (criteria-format.js): connectors, thresholds, logic words, split lists, notes. */
.join { display: inline-block; font-size: .72rem; font-weight: 700; letter-spacing: .05em; line-height: 1.5; padding: 0 6px; border-radius: 3px; vertical-align: 1px; }
.join-or { background: var(--accent-soft); color: var(--accent); border: 1px solid var(--accent); }
.join-and { background: var(--changed-bg); color: var(--changed-fg); border: 1px solid var(--changed-fg); }
.thr { font-weight: 700; background: var(--thr-bg); border-radius: 3px; padding: 0 2px; white-space: nowrap; }
b.logic { font-weight: 700; color: var(--accent-dark); }
.crit-list .split { display: grid; gap: 2px; margin: 4px 0 0 4px; }
.crit-list .split .item { display: block; padding-left: 16px; position: relative; }
.crit-list .split .glyph { position: absolute; left: 0; color: transparent; width: 12px; overflow: hidden; }
.crit-list .split .glyph::before { content: "•"; color: var(--muted); position: absolute; left: 2px; }
.crit-list .sent { display: block; margin-top: 6px; }
.crit-list strong.inline-head { display: inline; }
.crit-list br.fix-br + strong.inline-head::before { content: ""; display: block; margin-top: 6px; }
ins.fix { text-decoration: underline dashed var(--button); text-underline-offset: 3px; text-decoration-thickness: 1px; cursor: help; }
.crit-help ins.fix { cursor: default; }
.crit-list .crit-note { background: var(--accent-soft); border-left: 4px solid var(--accent); padding: 6px 10px; border-radius: 0 4px 4px 0; font-size: .95rem; }
.test { border-top: 1px solid var(--border); padding: 12px 0 4px; }
.test:first-of-type { border-top: 0; padding-top: 0; }
.test h4 { margin: 0 0 6px; font-size: 1rem; }
.test dl { margin: 0 0 8px; display: grid; gap: 2px; }
.test dl div { display: grid; grid-template-columns: 11em 1fr; gap: 8px; }
.test dt { color: var(--muted); font-size: .9rem; }
.test dd { margin: 0; overflow-wrap: anywhere; }
/* Whole genome sequencing tests and request forms */
:root { --wgs: #6a2a8c; --wgs-soft: #f3ecf8; }
@media (prefers-color-scheme: dark) { :root:not([data-theme="light"]) { --wgs: #d7b3ec; --wgs-soft: #33203f; } }
:root[data-theme="dark"] { --wgs: #d7b3ec; --wgs-soft: #33203f; }
.chip.wgs { background: var(--wgs-soft); color: var(--wgs); border: 1px solid var(--wgs); font-weight: 600; }
.test.test-wgs { border-left: 4px solid var(--wgs); padding-left: 12px; margin-left: -4px; background: linear-gradient(90deg, var(--wgs-soft), transparent 60%); border-radius: 0 4px 4px 0; }
.test-forms { margin: 8px 0 4px; }
.forms-head { margin: 0 0 2px !important; }
ul.forms { margin: 0 0 4px; padding-left: 18px; }
ul.forms li { margin: 1px 0; }
.s-request ul.forms-wgs li::marker { color: var(--wgs); }
.glh-pick { display: grid; gap: 2px; margin: 0 0 10px; font-size: .9rem; font-weight: 600; color: var(--muted); max-width: 360px; }
.glh-pick select { font: inherit; font-weight: 400; color: var(--fg); background: var(--card); border: 1px solid var(--muted); border-radius: 4px; padding: 6px 8px; }
.forms-for { margin: 8px 0 2px !important; font-weight: 600; }
.hub-finder { margin: 0 0 12px; }
.hub-finder summary { cursor: pointer; color: var(--accent); font-size: .9rem; }
.hub-finder ul { list-style: none; padding: 0; margin: 6px 0; display: grid; gap: 8px; }
.hub-finder li { padding: 6px 10px; border-left: 3px solid var(--border); }
.hub-finder li:has([aria-pressed="true"]) { border-left-color: var(--accent); }
.need-hub { padding: 6px 10px; background: var(--accent-soft); border-radius: 4px; }
.form-notes { margin: 8px 0; padding-left: 18px; }
.toolbar button.primary { color: #fff; background: var(--button); border-color: var(--button); font-weight: 600; }
.toolbar button.primary:hover { background: var(--button-hover); border-color: var(--button-hover); }
.panel { margin: 8px 0; }
.panel-name { margin: 0 0 2px; display: flex; flex-wrap: wrap; gap: 2px 8px; align-items: baseline; }
.panel summary { cursor: pointer; font-size: .9rem; color: var(--accent); }
.panel-change { margin: 4px 0 6px; padding: 6px 10px; background: var(--changed-bg); color: var(--changed-fg); border-radius: 4px; }
.panel-change a { color: inherit; }
.gene-find { display: grid; gap: 2px; margin: 8px 0 0; font-size: .85rem; font-weight: 600; color: var(--muted); max-width: 260px; }
.gene-find input { font: inherit; font-weight: 400; color: var(--fg); background: var(--card); border: 1px solid var(--muted); border-radius: 4px; padding: 4px 8px; text-transform: uppercase; }
.genes { margin: 8px 0 0; font-size: .9rem; line-height: 1.8; display: flex; flex-wrap: wrap; gap: 0 8px; max-height: 260px; overflow: auto; }
.genes a[hidden] { display: none; }
.pager { display: grid; grid-template-columns: 1fr auto 1fr; gap: 12px; align-items: center; margin: 20px 0 0; padding-top: 16px; border-top: 1px solid var(--border); }
.pager a { display: grid; gap: 2px; text-decoration: none; padding: 8px 12px; background: var(--card); border: 1px solid var(--border); border-radius: 4px; min-width: 0; }
.pager a:hover { border-color: var(--accent); }
.pager a.next { text-align: right; }
.pager-dir { font-size: .85rem; font-weight: 600; }
.pager-name { color: var(--fg); font-size: .9rem; overflow: hidden; text-overflow: ellipsis; white-space: nowrap; }
.pager a:hover .pager-name { text-decoration: underline; }

footer { border-top: 1px solid var(--border); padding: 20px 0 32px; color: var(--muted); font-size: .9rem; }
footer p { margin: 0 0 6px; }

/* Abbreviations */
abbr.abbr { text-decoration: underline dotted; text-underline-offset: 2px; cursor: help; }
abbr.abbr:hover { color: var(--accent); }
abbr.abbr[tabindex]:focus-visible { outline: 3px solid var(--focus); outline-offset: 1px; }
#abbr-tip { position: fixed; z-index: 1000; max-width: min(340px, calc(100vw - 16px)); padding: 6px 9px; border-radius: 4px; background: #212b32;
  color: #fff; font-size: .82rem; line-height: 1.35; pointer-events: none; box-shadow: 0 2px 8px rgb(0 0 0 / .25); }
:root[data-theme="dark"] #abbr-tip { background: #e6ecef; color: #11181d; }
@media (prefers-color-scheme: dark) { :root:not([data-theme="light"]) #abbr-tip { background: #e6ecef; color: #11181d; } }
#abbr-tip[hidden] { display: none; }
.glossary { margin-top: 16px; }
.glossary summary { cursor: pointer; font-weight: 600; }
.glossary dl { margin: 10px 0 0; display: grid; gap: 4px; }
.glossary dl div { display: grid; grid-template-columns: 7em 1fr; gap: 8px; }
.glossary dt { font-weight: 700; }
.glossary dd { margin: 0; }

/* Narrower screens: one column, with the tests and who can request them before the (long) criteria. */
@media (max-width: 960px) { #filter-fields { grid-template-columns: repeat(2, minmax(0, 1fr)); } }
@media (max-width: 820px) {
  .cols { display: flex; flex-direction: column; }
  .cols > div { display: contents; }
  .s-tests { order: 1; } .s-who { order: 2; } .s-request { order: 3; } .s-variant { order: 4; } .s-crit { order: 5; } .s-overlap { order: 6; }
}
@media (max-width: 640px) {
  .site-head { padding: 10px 0; }
  .brand { gap: 8px; }
  .brand-mark { width: 36px; height: 36px; }
  .brand h1 { font-size: 1.1rem; }
  .brand .pill { display: none; }
  #stats { display: none; }
  .long { display: none; }
  main { padding-top: 16px; }
  .intro { font-size: .95rem; margin-bottom: 10px; }
  .hint { display: none; }
  #search { margin-bottom: 12px; }
  #search button { padding: 0 12px; }
  #filter-fields { grid-template-columns: 1fr; }
  .test dl div { grid-template-columns: 1fr; gap: 0; }
  .block { padding: 14px; }
  .crit-list .lv1 { margin-left: 14px; } .crit-list .lv2 { margin-left: 28px; } .crit-list .lv3 { margin-left: 42px; }
  .pager { grid-template-columns: 1fr 1fr; }
  .pager-pos { grid-column: 1 / -1; grid-row: 1; text-align: center; }
}

/* Print: just the indication and its sources. */
@media print {
  body { background: #fff; color: #000; font-size: 11pt; }
  .site-head { background: none; color: #000; padding: 0 0 8px; border-bottom: 2px solid #000 !important; }
  .site-head a, .site-head .head-link, .brand-home, .brand-mark, .pill, #home, .back, .toolbar, .pager, .search-note, .gene-find, #abbr-tip { display: none !important; }
  .site-head h1 a { display: inline !important; color: #000; }
  .block, .sources { box-shadow: none; border-color: #999; break-inside: avoid-page; }
  .panel details:not([open]) { display: none; }
  .cols { grid-template-columns: 1fr 1fr; }
  a { color: #000; }
  a.src::after { content: " (" attr(href) ")"; font-size: 8pt; word-break: break-all; }
  abbr.abbr { text-decoration: none; }
  mark { background: none; color: inherit; }
  .layout-switch, .crit-help { display: none !important; }
  ins.fix { text-decoration: none; }
  .join { border: 1px solid #000; color: #000; background: none; }
  .thr { background: none; }
  footer { border-color: #999; }
}